Changs and its clinical significance of neuron-specific enolase and S-100? in serum and hippocampus in rats with epilepsy
- VernacularTitle:癫大鼠血清、海马组织中神经元特异性烯醇化酶和S-100?蛋白的变化及其临床意义
- Author:
Tingxian NIU
;
Xiaohong LUO
;
Zhiyong SHI
- Publication Type:Journal Article
- Keywords:
kainic acid;
epilepsy;
neuron-specific enolase;
S-100?
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change and its clinical significance of neuron-specific enolase (NSE) and S-100? in serum and hippocampus tissue in rats with epilepsy induced by Kainic acid (KA).Methods 180 Wistar rats were randomly classified into control, KA and carbamazepine (CBZ) group, and the later two groups were further divided into 6 sub-groups (1 h, 4 h, 12 h, 24 h, 48 h and 72 h ) according to epileptic attack at different time point. The NSE and S-100? concentrations in serum and homogenate of hippocampus were determined by radioimmunity assay (RIA) and enzyme linked immunosorbent assay (ELISA), respectively.Results The concentrations of NSE and S-100? were dynamic change during 72 h after epileptic attack in serum and hippocampus homogenate, and the changes were synchronous. The concentrations reached peak at 12 h. Both NSE and S-100? concentrations in KA and CBZ group were obviously higher than those in control group ( P
