Study on protective effect of Edaravone on dopamine transporter in rat models of Parkinson's disease
- VernacularTitle:依达拉奉对帕金森病大鼠多巴胺转运体保护作用的研究
- Author:
Guanhui WU
;
Shiyao BAO
;
Weifeng LUO
- Publication Type:Journal Article
- Keywords:
Edaravone;
Parkinson's disease
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Edaravone on dopamine transporter in rat models of Parkinson disease.Methods Rat models of Parkinson disease were induced by injection 6-OHDA into right medial forebrain bundle. Edaravone at different doses (3.0 mg/kg, 1.0 mg/kg or 0.3 mg/kg) was injected intraperitoneally twice daily for two weeks. The same dose of normal saline was injected in the control group. One week after the treatment, the ?-radiation of rat bilateral striatum, cerebral cortex and cerebella cortex of each group was measured by a ?-counter and the brain tissue ID value was calculated.Results There was a significant difference of the radiation count in right striatum between the large dose group (0.47?0.06) ,medium doss group(0.37?0.02)and the control group (0.25?0.01)( P
