Study on correlation between expression of ref-1 and neuronal apoptosis after intracerebral hemorrhage in rats
- VernacularTitle:大鼠脑出血后氧化还原因子-1表达与细胞凋亡相关性的研究
- Author:
Jiami WU
;
Shenghui CHEN
- Publication Type:Journal Article
- Keywords:
ICH;
redox factor-1;
apoptosis
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of redox factor-1 (Ref-1) and neuronal apoptosis around hematoma after experimental intracerebral hemorrhage (ICH) in rats.Methods ICH model of rat was induced using stereotactic infusion antilogous blood 50 ?l into the caudate nucleus. The male animals were randomly divided into sham operation group, normal control group and hemorrhage group. TUNEL and immunohistochemistry methods were used to detect apoptosis and the expression of Ref-1 in cerebral tissues at different time, respectively.Results The expression of Ref-1 was negatively correlated with neuronal apoptosis around hematoma after ICH (r=-0.745, P
