Intervention effect of local application of recombinant hirudin on neuronal apoptosis in intracerebral hemorrhage of rats
- VernacularTitle:局部应用重组水蛭素对大鼠脑出血神经细胞凋亡的干预作用
- Author:
Zhonghe ZHOU
;
Fang QU
;
Xiang HE
- Publication Type:Journal Article
- Keywords:
hirudin;
thrombin;
apoptosis;
intracerebral hemorrhage
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the intervention effect of recombinant hirudin on apoptosis of neurons in intracerebral hemorrhage (ICH) of rats.Methods ICH animal models were established by autologous blood injection, and hirudin, a special inhibitor of thrombin, was used for intervention treatment. The neurologic impairment scores (NIS) of rats were measured, and TUNEL-positive cells and caspase-3 IR cells were also detected in cortex and basal ganglia 24 h after operation.Results After intervention treatment of recombined hirudin, the NIS of rats decreased obviously ( P
