The expression level of hypoxi-inducible factor-1? in bone marrow biopsies of acute leukemia and the relationship with angiogenesis
- VernacularTitle:急性白血病骨髓组织中低氧诱导因子-1?表达与血管生成关系的研究
- Author:
Zhenzhang CHEN
- Publication Type:Journal Article
- Keywords:
Acute leukemia;
HIF-1?;
Microvascular density;
Plastic-embedded section;
Bone marrow biopsy
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
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Abstract:
Objective: To explore the expression level of hypoxi-inducible factor-1? and the relationship with angiogenesis in bone marrow biopsies of acute leukemias. Methods: Bone marrow biopsies from 10 controls and 20 acute leukemias were embedded in glycol-methacrylate(GMA) resin.EnVison two-step immunohistochemical staining method was used to show the expression level of HIF-1? and microvessel density.Results: The low expression level of HIF-1? protein in acute leukemias was observed in 1 case,middle level in 5 cases,high level in 6 cases and very high level in 8 cases,while in controls,high level in 3 cases and middle level in 7 cases.There was statistical significance between two groups(P
