Relativity among PreS1-antigen,HBV Markers and HBV-DNA
- VernacularTitle:前S1抗原与HBV血清标志物及HBV-DNA相关性的探讨
- Author:
Xiaomei LIN
;
Zhihua TAO
;
Wu ZHOU
;
Wenhui ZHANG
;
Yumin WANG
- Publication Type:Journal Article
- Keywords:
HBV-DNA;
PreS1-antigen;
Hepatitis B;
HBV markers
- From:
Chinese Journal of Nosocomiology
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the relativity among PreS1-Antigen,HBV markers and HBV-DNA. METHODS The HBV markers,PreS1-antigen and HBV-DNA were determined by ELISA and PCR in 102 patients with chronic hepatitis B and 73 healthy persons. RESULTS Among 102 patients with chronic hepatitis B,the concordance rate of PreS1-antigen and HBeAg with HBV-DNA was 70.6% and 75.5%.The sensitivity of PreS1 was better than HBeAg but the specificity was contrary.It represented some patients with HBeAg(-) still had viral replication.On the increase in the level of HBV-DNA,the positive rates of PreS1-antigen and HBV markers increased. CONCLUSIONS The detection of PreS1-antigen can well reflect the HBV replication.The synchronous dynamic detection of PreS1-Antigen,HBV markers and HBV-DNA has its important clinical meaning.
