Progress in Protein-protein Docking Approaches
- VernacularTitle:蛋白质-蛋白质分子对接方法研究进展
- Author:
Chunhua LI
;
Xiaohui MA
;
Weizu CHEN
;
Cunxin WANG
- Publication Type:Journal Article
- Keywords:
protein-protein docking, filtering, scoring function, molecular flexibility
- From:
Progress in Biochemistry and Biophysics
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Protein-protein interactions and recognition are the focal and hot themes of the life science field in the 21st century. Molecular docking approach is the effective computer modeling technology in the study of this topic. Generally, the protein-protein docking procedure is composed of four stages: searching of the binding modes of the receptor and the ligand, filtering of docked modes to eliminate the irrational docked structures, optimizing the structures, evaluating the docked modes with the refined scoring function and ranking them to obtain the near-native structures. Combining the research group's works, in terms of the international and national progress of protein-protein docking approaches, the detailed review was made about the four stages mentioned above. Additionally, the existing major questions are analyzed and the prospects of the future study are made.
