Role of thiopurine methyltransferase measurement prior to treatment of IBD with AZA/6-MP
- VernacularTitle:硫唑嘌呤/6-巯嘌呤治疗炎性肠病前检测硫嘌呤甲基转移酶的临床意义
- Author:
Sifang LIU
;
Xiaohong LIU
- Publication Type:Journal Article
- Keywords:
inflammatory bowel disease;
azathioprine;
6-mercaptopurine;
thioprine methyltransferase
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Azathioprine(AZA) and 6-mercaptopurine(6-MP) have a well-established effect as an immunosuppressive agent for inflammatory bowel disease(IBD),Myelosuppression is the most serious side effect during treatment.Thiopurine methyltransferase(TPMT) plays an important role in the metabolism of 6-MP. This article reviews the literature on the role of TPMT measurement prior to treatment of IBD with AZA/6-MP.
