Changes of spasmolysant airways in different phases in asthmatic guinea pigs
- VernacularTitle:哮喘豚鼠模型痉挛气道的解痉挛规律
- Author:
Zehua DONG
- Publication Type:Journal Article
- Keywords:
asthma;
spasm;
bronchodilation test;
disease models,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the linearic regularity of airways′ spasm and spasmolysis in hyperreactive guinea pigs.Methods Asthmatic guinea pig models were established with acetylcholine(Ach).Then the animals inhaled salbutamol.At 0,15,30 min and 1 h after inhalation of salbutamol,the animals were sacrificed,and the small and large airways were fixed with formaldehyde and embedded in paraffin wax to acquire the consecutive slides.The pathologic changes of both the large and small airways were observed and the caliber changes of the airways were determined.Results The diameters of small and large airways of the control guinea pig models(0.41?0.10 and 1.78?0.41 mm,respectively) were significantly short than that in normal(0.55?0.20 and 2.41?0.50 mm,respectively)(P
