Toxicity of benzene combined with formaldehyde on reproductive cells in mice
- VernacularTitle:苯和甲醛对雄性小鼠睾丸生殖细胞的联合毒性
- Author:
Ling LI
;
Tiegang QUAN
;
Guangyan YU
;
Tieji LI
- Publication Type:Journal Article
- Keywords:
benzene/toxicity;
formaldehyde/toxicity;
combing poison;
sperm count;
rate of sperm deformation;
superoxide dismutase
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the toxicity of benzene combining with formaldehyde on reproductive cells in mice.Methods Male mice were randomly divided into different groups:three experimental groups with different doses of benzene combining with formaldehyde(mg?kg~(-1))(10+10,50+50 and 100+100),control group and vegetable oil group(n=10).After 8 weeks by oral poison,the mice were killed,testis was weighed,sperm count was peformed,the rate of sperm deformation was counted and the SOD activity was measured.Results The quantities of sperm in various poison groups were obvious decreased and the rate of sperm deformation were obvious increased with dose increasing.Compared with control group,they both had obvious difference(P
