Effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea
- VernacularTitle:甲基汞对豚鼠耳蜗外毛细胞外向钾电流的影响
- Author:
Shufang LIU
;
Xiaofeng GUO
- Publication Type:Journal Article
- Keywords:
methylmercury;
hair cells;
outward potassium currents;
patch clamp techniques
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea.Methods The whole-cell patch clamp technique was used.Calcium sensitive outword potassium currents were recorded when the concentrations of mercurial were 1/1000 LD_(50),1/100 LD_(50) and 1/10 LD_(50).Results After methylmercury poisoning,amplitudes of the outword potassium currents I_(K(Ca)) were(1.48?0.28),(1.36?0.16) and(1.22?0.13)nA.Compared with control group,the amplitudes in three methylmercury poisoning groups were decreased by 8%,16% and 25%(P
