Effects of chemotherapeutic drugs on proliferation of tongue carcinoma cells
- VernacularTitle:化疗药物对舌癌细胞增殖能力的影响
- Author:
Wenzhi HAN
;
Yingxin CHEN
- Publication Type:Journal Article
- Keywords:
tongue neoplasms;
mitomycin/pharmacology;
fluorouracil/pharmacology;
cisplatin/pharmacology;
cell cycle;
drug screening assays,antitumor;
taxol
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of paclitaxel,mitomycin,5-FU and cisplatin on the proliferation of tongue carcinoma cells and to guide the reasonable using of chemotherapeutic drugs and avoids the side-effects.Methods The fresh tongue carcinoma tissues from surgery were collected and unicellular suspension were prepared.Then paclitaxel,mitomycin,5-FU and cisplatin were used to investigate the drug sensitivity on primary tongue carcinoma cells and a blank control group was set up.The inhibitory effects of chemotherapeutic drugs on the growth of tongue carcinoma cells and the cell cycle phases were observed by MTT colorimetry and flow cytometry.Results The inhibitory rates of paclitaxel,mitomycin and 5-FU on tongue carcinoma cell proliferation were 45.3%,37.3%,and 36.2%,respectively,and in control group it was 2.1%,the difference was significant(P
