Meta-analysis of prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy
- VernacularTitle:准分子激光屈光性角膜切削术中应用丝裂霉素C预防角膜上皮下雾状混浊形成的meta分析
- Author:
Huang WU
;
Chunyong WANG
- Publication Type:Journal Article
- Keywords:
mitomycin/therapeutic use;
keratectomy,photorefractive,excimer laser/methods;
haze;
meta-analysis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy(PRK).Methods Both a computer-aided search of Medline,OVID,CNKI,Wanfang data and an intensive search by hand were conducted to identify all randomized controlled trials assessing the effect of intraoperative using mitomycinC during PRK.Results Two studies were finally included.The Q test of homogeneity showed no difference between them(?~2=0.17,df=1,P=0.68).The OR value of the studies were 0.17[95% CI 0.05-0.53] and 0.10[95% CI 0.01-0.85],respectively;the pooled OR was 0.14 [95% CI 0.05-0.40],significant difference was found between experimental group and control group(Z=3.75,P=0.000 2).Conclusion Topical intraoperative application of 0.02% mitomycin-C can reduce haze formation in patients with highly near-sightedness after PRK.
