Impacts of rhG-CSF on neutrophilic granulocytes and their surface molecules expression
- VernacularTitle:重组人粒细胞集落刺激因子对中性粒细胞及其表面分子表达的影响
- Author:
Xinli DENG
;
Wenrong HUANG
;
Yulong CONG
;
Deyong ZOU
- Publication Type:Journal Article
- Keywords:
recombinant human granulocyte-colony stimulating factor(rhGCSF);
neutrophilic granulocyte;
surface molecules
- From:
Chinese Journal of Clinical Laboratory Science
1985;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate injecting recombinant human granulocyte-colony stimulating factor(rhG-CSF) on the proportion of peripheral neutrophilic granulocyte and their surface molecules expression in healthy people.Methods The peripheral blood samples were collected from the healthy people who were injected with rhG-CSF.The expressions of CD62L,CD11a,CD44 and CD49d on the surface neutrophilic granulocytes were determined before and after injection with flow cytometery.Results The median percentage of neutrophilic granulocytes in peripheral blood leucocytes after injecting rhG-CSF significantly increased from 60% to 85%(P0.10).Conclusion Injecting rhG-CSF may obviously impact the expression of CD62L and CD49d on neutrophilic granulocytes.
