Effect of Ginsenosides on Memory Retention of Rats in Animal Models of Schizophrenia
- VernacularTitle:人参皂甙对精神分裂症动物模型大鼠记忆保持的影响
- Author:
Yongli GAO
;
Wenqiang HAN
;
Jie DAI
- Publication Type:Journal Article
- Keywords:
schizophrenia;
animal models;
MK801;
memory retention;
Ginsenosides
- From:
Chinese Mental Health Journal
2002;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of ginsenodels on the memory retention of rats of animal models of schizophrenia.Methods:The rats in experiment were divided into experimental group and control group, the rats in the experimental group were orally given Ginsenosides, and rats in control group were given normal saline. Both groups were treated for 5 days, then given injection of MK801 to establish animal models of schizophrenia. Before (d0), during (d1,d3) and after (d5) MK801. Several behavior models such as active avoidance reaction (AAR) and once passive avoidance reaction (OPAR) were used to research the process of learning and memory before and after experimental.Results:In the active avoidance reaction, the rats of experimental group were used to increase, and the fade away slowed to the rats of controls groups significantly (231.79?18.90/158.28?6.78,134.86?15.49/92.29?9.22,81.64?17.29/36.08?17.12,t=10.35,6.68,5.29,P
