Effect of Mirtazapine on Depression after Cerebral Infarction and Rehabilitation of Neurological Functions
- VernacularTitle:米氮平治疗脑梗死伴发抑郁患者的疗效及其对神经功能康复的影响
- Author:
Jianjun MA
;
Xue LI
;
Yan FENG
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
depression;
mirtazapine;
neurological function;
rehabilitation
- From:
Chinese Mental Health Journal
2002;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the efficacy of mirtazapine in the treatment of depression after cerebral infarction and its effect on rehabilitation of neurological functions. Methods:117 patients with acute cerebral infarction comorbid with major depression were randomly allocated to two groups treated with mirtazapine (57 cases) or not (60 cases). Hamiltion Depression Rating Scale (HAMD), Zung's Self-rating Depression Scale(SDS), modified Edingburgh-Scandinavian Stroke Scale (SSS) and Activity of Daily Living(ADL) were measured at baseline, 2 weeks, 4 weeks, 8 weeks and 6 months after randomization.Results:At the end of 6 months trial, the effective rate for depression of mirtazapine group was 100%, including 41 with relief (41/57, 71.9%); while that of control group was 13.4% (3/60), with only 4 with relief (6.7%). For neurological function, 78.9% (45) patients in mirtazapine group had significant improvement, that number in control group was 31 (51.7%). From the third week, patients in mirtazapine group had better ADL results than baseline (31.2?11.2/39.2?15.8), at the end of 6 months, their activity of daily life was much better than that of control (15.7?5.4/21.8?9.7, t=4.17,P
