Establishment of an acute cerebral ischemia-reperfusion rat model and evaluation by scanning of perfusion CT
- VernacularTitle:大鼠急性脑缺血再灌注模型的建立及CT灌注扫描的评价
- Author:
Xiaobo ZHANG
;
Zhengyu JIN
;
Mingli LI
;
Huadan XUE
;
Wanchen DOU
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
reperfusion;
models;
perfusion CT
- From:
Basic & Clinical Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the reliability of a rat model of acute cerebral ischemia and reperfusion by using cerebral perfusion functional CT.Methods A stable and reversible focal ischemia model with unilateral middle cerebral artery occlusion was established and evaluated by CT perfusion imaging and TTC staining.Results Artificial Occlusion of the MCA resulted in ipsilateral cerebral infarcts in all study animals.Hypoperfusion was definitely recorded in all CT perfusion images obtained after MCA occlusion and was significantly correlated with the final lesion size.Blood flow was restored after pulling the thread out of the artery.Conclusions The method of establishing an acute focal cerebral ischemia and reperfusion model by thread insertion in our study is simple and stable.If we can screen the stroke model with CT perfusion examination,the error caused by variance of model can be reduced.Thereby it provides a platform for researchers to investigate acute cerebral ischemia and recirculation.
