Effects of docosahexaenoic acid (DHA) compound on H-Ras and p16 mRNA transcription in gastric adenocarcinoma
- VernacularTitle:二十二碳六烯酸(DHA)复合物对胃腺癌细胞内H-Ras和p16 mRNA含量的影响
- Author:
Dong CHENG
;
Xiaoying HAN
;
Hui LI
;
Li ZHAO
;
Keren SUN
- Publication Type:Journal Article
- Keywords:
docosahexaenoic acid(DHA);
apoptosis;
H-Ras;
p16
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antitumor mechanism of DHA compound. Methods RT-PCR was used to investigate the effects of DHA compound on H-Ras and pl6 mRNA transcription in gastric adenocarcinoma. Results Compared with control, the content of H-Ras mRNA was decreased and the content of p16 mRNA was increased in gastric adenocarcinoma significantly after treated with DHA compound. Conclusion The transcription of H-Ras gene was decreased and the transcription of pl6 gene was increased in gastric adenocarcinoma after treated with DHA compound and thus the cancer cell growth was inhibited.
