Effect of polysaccharide from Porphyra on spleen cell function in immunosuppressive mice
- VernacularTitle:紫菜多糖对免疫低功小鼠脾细胞功能的影响
- Author:
Jun LIU
;
Changlong LU
;
Qinghui WANG
;
Ji LI
- Publication Type:Journal Article
- Keywords:
polysaccharide from Porphyra;
cyclophosphamide;
immunosuppressive mice
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of polysaccharide from Porphyra on spleen cell function in immunosuppressive mice. Methods The polysaccharide at dosages 0.025, 0.050 and 0.150g?kg~ -1 was injected intraperitoneally for 7 days in the immunosuppressive mice induced by cyclophosphamide. On day 8, the splenic lymphocytic proliferation and activity of TNF were determined. Results The splenic lymphocytic proliferation and cytotoxicity of tumor necrosis factor (TNF) of the group treated with 0.150g?kg~ -1 of porphyra polysaccharide were higher than those of model group. Conclusion Polysaccharide from Porphyra could promote splenic lymphocytic proliferation and raise the level of TNF.
