Association between genetic polymorphisms of exon3 of nicotinic acetylcholine receptor ?4 subunit and sporadic Alzheimer's disease
- VernacularTitle:神经型尼古丁胆碱能受体?4亚单位基因外显子3基因多态性与散发性Alzheimer病的关系
- Author:
Yanfei QI
;
Keren SHAN
;
Ying XU
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease,sporadic;
nicotinic acetylcholine receptor ?4 subunit;
genetic polysmorphism
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between genetic polymorphisms of exon3 of nicotinic acetylcholine receptor ?4 subunit (CHRNA4) and sporadic Alzheimer's disease(SAD).Methods In 23 SAD patients and 30 people of normal control, exon3 of CHRNA4 was screened by PCR-DGGE and DNA sequencing.Results Three new genetic polymorphisms were found in the exon3 of CHRNA4: C104T, A136G, G169A.The frequnces of these three genes in SAD group were 35%,46%,61% respectively and in control group were 13%,13%,33% respectively. There were significant difference between two groups (all P
