Diagnostic value of oligoclonal bands and intrathecal IgG synthesis rate in multiple sclerosis
- VernacularTitle:寡克隆带和IgG鞘内合成率对多发性硬化的诊断价值
- Author:
Bin LI
;
Li GUO
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
multiple sclerosis;
oligoclonal bands;
intrathecal IgG synthesis rate
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the sensitivity and specificity of oligoclonal bands (OCBs) and intrathecal IgG synthesis rate (IgG Syn) for diagnosis of multiple sclerosis (MS) and the correlation between qualitative and quantitative indices.Methods Albumin and IgG concentrations in the cerebrospinal fluid (CSF) and serum from 30 patients with MS, 40 with other nervous system inflammatory diseases (NID) and 22 with nervous system noninflammatory diseases (NNID) were determined by rate nephelometry method. OCBs in the CSF were detected using isoelectric focusing combined with silver staining, and IgG Syn was calculated. The sensitivity, specificity and positive result likelihood ratio (PRLR) were analyzed.Results There were no significant difference in the abnormal rate of OCBs and IgG Syn between MS group and NID group. When MS and NID groups were compared with NNID group, the difference was extremely significant (all P
