Exparimental study on relationship between GAT-1 and neuron injury in focal cerebral ischemia/infusion model
- VernacularTitle:?-氨基丁酸转运体-1与局灶性脑缺血再灌注神经元损伤关系的实验研究
- Author:
Fangfang BI
;
Fafa TIAN
;
Bo XIAO
- Publication Type:Journal Article
- Keywords:
GAT-1;
ischemia/reperfusion
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between GAT-1 and neuron injury in focal cerebral ischemia/infusion model.Methods Focal cerebral ischemia/reperfusion models were established in rats by thread embolic, then the brain tissues were taken at 3 h, 6 h,12 h, 24 h and 3 d after cerebral ischemia/reperfusion.The number of GAT-1 positive neurons were calculated and the average optical density were detected by immunohistochemical technique in different time points after cerebral ischemia/reperfusion, compared with the normal group and the sham operated group.Results The expression of GAT-1 was up-regulation obviously at 3 h after cerebral ischemia/reperfusion( P
