Role of aquaporin-4 on cerebral ischemia/reperfusion injury in rats
- VernacularTitle:水通道蛋白4在大鼠脑缺血再灌注损伤中的作用
- Author:
Yinghui CHEN
;
Yongbo ZHAO
;
Dengjun GUO
- Publication Type:Journal Article
- Keywords:
cerebral ischemia/reperfusion;
cerebral edema;
aquaporin-4;
blood-brain barrier
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investgate the role of aquaporin-4(AQP4) in secondary cerebral edema after ischemia/reperfusion injury in rats.Methods When the models of reversible middle cerebral artery occlusion were established, the alterations of cerebral edema and BBB were evaluated by measuring water and Eval's Blue (EB) contents of cerebral tissue, and the expression of AQP4 in brain was observed by Western Blot at different time point after reperfusion. At last, the correlation between expression of AQP4 and water and EB contents of cerebral tissue were analysed.Results There were found that water and EB contents of cerebral tissue in rat models significantly higher than those of control group at different time point after ischemia/reperfusion ( P
