Expression and characteristic distribution of gamma-aminobutyric acid and its receptors in submandibular gland of the rat
- VernacularTitle:?-氨基丁酸及其受体在大鼠颌下腺表达和分布特征
- Author:
Ling GONG
- Publication Type:Journal Article
- Keywords:
Gamma-aminobutyric acid;
Receptor;
Submandibular gland;
Rat
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expression of gamma-aminobutyric acid(GABA)and GABA receptors in the epithelial cells of rat submandibular gland. Methods:Immunocytochemical expression of GABA and GABA receptors in submandibular gland of SD rat was investigated by EnVision techniques.Furthermore,the distribution pattern and the functional implications of GABA system were assessed.Results:Immunoreactive GABA was detected in both acinar and ductal cells in the submandibular gland of SD rat.Strong staining for GABA was localized mainly in the cytoplasm near the basement side of epithelial cells of the excretory and striated ducts.GABA-A receptor a1 subunit was positively expressed in the acinar and ductal cells,while GABA-B receptor R1 and R2 subunit was only slight expressed in the epithelial cells of the striated ducts.However,no staining for GABA-A receptor b2 subunit was found in the submandibular gland of SD rat. Conclusion:The expression of GABA and its receptors in the epithelial cells of rat submandibular gland suggests that GABA system might be involved in the secretion and/or excretion of saliva in the rat.
