The associations of single nucleotide polymorphisms on bactericidal/permeability-increasing protein and lipopolysaccharide-binding protein with the susceptibility of infection
- VernacularTitle:杀菌性/通透性增加蛋白和脂多糖结合蛋白基因多态性与易感性的相关研究
- Author:
Weijian LENG
- Publication Type:Journal Article
- Keywords:
Bactericidal/permeability-increasing protein;
Lipopolysaccharide-binding protein;
Single nucleotide polymorphism;
Sepsis
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the associations of single nucleotide polymorphisms(SNP) on bactericidal/permeability-increasing protein(BPI) and lipopolysaccharide-binding protein(LBP) with the complication of sepsis. Methods: The SNP genotypes of BPI Lys216Glu,PstⅠin intron 5,G545C,LBP Cys98Gly and Leu436Pro were examined by restriction fragment length polymorphism PCR(PCR-RFLP).Results:The rate of BPI Lys216Glu G/G genotypes and G-alleles in patients with sepsis were significantly higher than that of volunteers.The rate of BPI Lys216Glu G/G genotypes and G-alleles in nonsurviving patients were significantly higher than that of survivor patients. Conclusion: The BPI Lys216Glu G-allele may be associated with the high risk of sepsis.
