Screening the PGC-1? gene for SNPs and analyzing PGC-1? Gly482Ser mutation in Chinese population
- VernacularTitle:2型糖尿病PGC-1?基因单核苷酸多态性筛查及Gly482Ser变异分析
- Author:
Wensheng LU
;
Hua CHENG
;
Qin HUANG
- Publication Type:Journal Article
- Keywords:
PGC-1? gene;
SNP;
Mutative protein;
Diabetes mellitus,type 2
- From:
Chinese Journal of Diabetes
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The study of subjcts with T2DM (n=120) and NGT (n=106) in using the screening of PGC-1? gene for SNPs by PCR-SSCP and DNA sequencing showed that four SNPs(Thr394Thr、Gly482Ser、Thr528Thr、Thr612Met) in the PGC-1? gene were found in 50 Han Chinese type 2 diabetic patients.A Gly482Ser polymorphism of PGC-1? gene was associated with type 2 diabetes.[
