Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis.
10.4046/trd.2006.60.5.523
- Author:
Jae Woo JUNG
1
;
Young Woo LEE
;
Jae Cheol CHOI
;
Seung Min YOO
;
Hwa Yeon LEE
;
Seoung Young LIM
;
Jong Wook SHIN
;
Jae Yoel KIM
;
In Whn PARK
;
Mi Kyung KIM
;
Byoung Whui CHOI
Author Information
1. Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. basthma@hanmail.net
- Publication Type:Original Article
- Keywords:
Tuberculosis;
Lymph Node;
S-100b;
Dendritic Cells
- MeSH:
Antigen Presentation;
Antigen-Presenting Cells;
Cough;
Dendritic Cells*;
Fever;
Granuloma;
Incidence;
Logistic Models;
Lymph Nodes;
Lymphatic Diseases;
Mycobacterium tuberculosis;
Radiography;
Retrospective Studies;
Tuberculosis;
Tuberculosis, Lymph Node*;
Tuberculosis, Pulmonary
- From:Tuberculosis and Respiratory Diseases
2006;60(5):523-531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes. METHODS: A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A x2 test, unpaired T test and multiple logistic regression analysis were performed. RESULTS: Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was 113.0+/-7.0. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever. CONCLUSION: Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy.
