The Role of E3 Ubiquitin Ligase Smurfs in BMP and TGF-bata Signaling in Bone Cells
- VernacularTitle:E3泛素连接酶Smurf家族在骨形态发生蛋白和转化生长因子信号转导中的作用
- Author:
Qing WANG
;
Tianhui ZHU
;
Ming ZHANG
;
Di CHEN
- Publication Type:Journal Article
- Keywords:
ubiquitin-proteasome system, E3 ubiquitin ligase, Smurf, bone morphogenetic proteins (BMPs), transforming growth factor-? (TGF-?), osteoblast, chondrocyte
- From:
Progress in Biochemistry and Biophysics
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The ubiquitin-proteasome system is composed by multiple enzymes which are ubiquitously expressed in mammalian cells and plays an essential role in a variety of biological processes. As key members of the protein degradation enzymatic system, the function of E3 ubiquitin ligases has been extensively investigated. BMP and TGF-? are critical molecules that regulate proliferation, differentiation and apoptosis of osteoblasts and chondrocytes through different signaling pathways. Resent findings indicate that the ubiquitin-proteasome system functions as a key regulator in bone cells and the E3 ligase mediates the proteolytic degradation of critical molecules in BMP and TGF-? signaling pathways. Recent progress on studies of HECT domain E3 ligase, Smurf, in osteoblasts and chondrocytes were summarized. The regulatory role of Smurf1 and Smurf2 in BMP and TGF-? signaling and osteoblast and chondrocyte function has been reviewed.
