Effects of long-term,low-dose hormone replacement therapy on serum level of c-reactive protein and homocysteine in postmenopausal women
- VernacularTitle:长期小剂量性激素替代疗法对绝经后妇女血清CRP及同型半胱氨酸水平的影响
- Author:
Min NIE
;
Meili SUN
;
Yaohong SONG
;
Ying SHEN
;
Qinsheng GE
- Publication Type:Journal Article
- Keywords:
low-dose;
hormone replacement therapy;
c-reactive protein;
homocysteine
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of long-term,low-dose hormone replacement therapy(HRT) on serum level of creactive protein(CRP) and homocysteine(Hcy) in postmenopausal women.Methods A total of 141 postmenopausal women were selected from medical staff of the Peking Union Medical College Hospital.Of these,63 subjects have been treated with low-dose sex hormone for over 5 years(HRT group),78 subjects have never received hormone replacement therapy as control group.The serum levels of CRP and Hcy in two groups were evaluated.Results The serum level of estradiol(E_2) in HRT group was significant higher than that in control group(median,inter-quartile range;33.8 ng/L,30.9 vs 21.3 ng/L,33.2)(P0.05).There was no correlation between the serum level of CRP,Hcy and the plasma levels of E_2 and FSH respectively.Conclusion Long-term and low-dose HRT does not increase the serum level of CRP and Hcy in postmenopausal women.
