Inhibitory effects of novel heteropoly compounds on influnenza virus (H1N1) in vitro
- VernacularTitle:新型杂多化合物的体外毒性和抗流感病毒活性
- Author:
Yun PU
;
Xin ZHANG
;
Juan LI
;
Hongfang WANG
;
Xuejing LI
- Publication Type:Journal Article
- Keywords:
heteropoly compounds;
influenza A virus/drug effects;
cytopathic effect,viral/drug effects
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the toxicities and inhibitory effects of three kinds of kegin-type novel heteropoly compounds which were synthesised by molecular assembly interactions on influnenza A virus(H1N1) in vitro.Methods The toxicities and anti-influnenza virus activities were tested by methods of CPE-MTT and chick embryos culture.Results TC_(50) in MDCK cells and LD_(50) in chick embryos of three kinds of kegin-type novel heteropoly compounds were higher than those of amantadine.TI in MDCK cells and chick embryos were both higher than that of amantadine. Conclusion The three kinds of kegin-type novel heteropoly compounds have lower toxicities and higher anti-virus effects on influnenza A virus(H1N1) than amantadine.Through chemic modifications,the toxicity of amantadine can be decreased and the activity of amantadine can be increased.
