Protective effects of total glycosides of Pacony on acute myocardial ischemia in dogs
- VernacularTitle:白芍总苷对犬急性心肌缺血的保护作用
- Author:
Xiaoming WANG
;
Fubiao LI
;
Wenwei LU
;
Xia CHEN
- Publication Type:Journal Article
- Keywords:
radix paeoniae alba;
myocardial infarction/drug therapy;
epicardium electrocardiogram;
myocardial enzymes;
reactive oxygen species
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of total glycosides of Pacony(TGP) on acute myocardial infarction in dogs.Methods Thirty domestic dogs were randomly divided into 5 groups(6 in each group): model control group,positive control group(ISM),and TGP groups with doses of 2.0,4.0,and 8.0 mg?kg~(-1),respectively.The descending branch of left coronary artery was ligated to construct the model of myocardial infarction in the anesthetic thoraco-opened dogs.The effect of TGP on epicardium electrocardiogram(EECG),myocardial infarction size(MIS) and serum myocardial enzymes were observed.Results Compared with controls,the ischemia degree(∑-ST,P
