Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats
- VernacularTitle:溶血磷脂酸对急性心肌梗塞大鼠并发心律失常的影响
- Author:
Xuexin ZHANG
;
Chunyan ZHAO
- Publication Type:Journal Article
- Keywords:
lysophospholipids;
myocardial infarction;
arrhythmia;
disease models,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of lysophosphatidic acid(LPA) on arrhythmia in acute myocardial infarction(AMI) rats.Methods AMI models were prepared by ligating the left coronary branch of rats.60 Wistar rats were divided into 5 groups:sham-operated(SO),AMI,AMI+LPA,AMI+pertussis toxin(PTX) and(AMI+)PTX+LPA.ECG were recorded,HR and VPBs were observed as important indexes.Results Incidence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group(P
