Effects of ginseng fruit saponins(GFS)on coronary circulation and myocardial oxygen metabolism in dogs with acute myocardial infarction
- VernacularTitle:人参果皂苷对急性心肌梗塞犬冠状动脉循环及心肌氧代谢的影响
- Author:
Yi WU
;
Xiaofeng YU
;
Shaochun QU
;
Dayuan SUI
- Publication Type:Journal Article
- Keywords:
ginseng fruit saponins;
myocardial infarction;
coronary circulation;
myocardial oxygen metabolism;
disease models,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of ginseng fruit saponins(GFS)on the coronary circulation and cardial oxygen metabolism in dogs with acute myocardial infarction.Methods The acute myocardial infarction model was induced by ligating the left anterior descending coronary of dogs for 6 h.90 min after treatment with GFS,the blood flow of coronary artery was determined by using electromagnetism flowmeter with MP-27 type.At the same time,the blood oxygen contents of artery and vein were determined by using analysis instrument of blood gas with CORNIHG 178 type.Results After treated by GFS(in a dosage of 5 and 10 mg?kg~(-1) iv drip for 90 min),the myocardial blood flow(MBF) was increased and coronary vascular resistance(CVR) was decreased significantly.Meanwhile the cardiac oxygen consumption and myocardial oxygen utilization rate were also decreased,but cardiac oxygen consumption index had not changed significantly.Conclusion GFS has protective effects on acute myocardial ischemia through improving the coronary circulation,increasing myocardial blood supply and decreasing cardiac oxygen consumption and myocardial oxygen utilization rate.
