Antagonism of Chinese medicine herbals on chromsome breakage induced by Bleomycin
- VernacularTitle:中药合剂对博莱霉素所致人染色体断裂的拮抗作用
- Author:
Bing LIU
;
Lu LI
;
Yang LIU
;
Jun LIU
- Publication Type:Journal Article
- Keywords:
mutagens;
chromosome breakage;
drugs,Chinese herbals;
Bleomycin
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antagonsim of Chinese medicine herbals on the chromsome breakage induced by Bleomycin(BLM),which was composed of ginseng,cortex acanthopanasia radices(CAR),pachyna cocos Fr.and angelica at certain concentration.Methods The mutagen sensitivety test was used to detect the effect of BLM on chromatid breaks per cell from peripheral blood lymphocytes of 20 healthy subjects.And the infuence of Chinese medical herbals on the stability of chromsome was studied.50 cells per sample were observed under microscope and then the average b/c value(chromatid breaks per cell) of every group was calculated.The all b/c values were analyzed by statistical method.Results There was obvious difference of the b/c value between BLM group and negative group(P
