Expression of tumor suppressor gene product Rb protein in breast cancer and its clinical significance
- VernacularTitle:抑癌基因产物Rb蛋白在乳腺癌中的表达及其临床意义
- Author:
Meirong ZHAO
;
Yilei LI
- Publication Type:Journal Article
- Keywords:
genes,tumor suppressor;
retinoblastoma protein;
breast neoplasms
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of retinoblastoma(Rb) protein in patients with breast cancer and its significance.Methods The expressions of Rb protein were detected in 52 patients with breast cancer,20 patients with breast fibroadenoma or breast cystic hyperplasia(control group) by S-P immunohistochemical method.(Results The negative) rate of Rb expression in breast cancer(76.91%) was higher than that in control group(15.00%)(P0.05).Of all 46 follow-up patients with breast cancer,the peritoneal recurrence and metastatic rate was 10.53% in 38 cases of the negative expression of Rb protein,and while the rate was 0 in 8 cases of the positive expression of Rb protein,there was significant difference(P
