Histopathological changes of bowenoid papulosis and its relationship with apopotosis
- VernacularTitle:鲍温样丘疹病组织病理学变化及其与细胞凋亡的关系
- Author:
Xifu LIU
;
Yan YU
;
Aihua FU
;
Xiaoli WANG
- Publication Type:Journal Article
- Keywords:
bowenoid papulosis;
apoptosis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the histopathological changes and biological behavior of bowenoid papulosis and its relationship with apopotosis.Methods 20 bowenoid papuloses and 5 normal skin tissues were examined by DNA nick end labeling(TUNEL) technique and the pathological changes of bowenoid papulosis were observed by Hematoxylin-eosin-stained.Results Bowenoid papulosis exhibited disordered maturation and scattered,large,highly atypical cells mitoses throughout all layers of epithelium;and there were few apoptotic cells in 5 normal skin tissuese and many apoptotic cells in bowenoid papuloses.The apoptotic index(27.1?15.1) in bowenoid papulosis patients was significantly higher than that in control group(6.8?3.5)(P
