Fas-FasL and TNF-? Mediated Apoptosis and IL-8 Associated with Pathogenesis of Aged Chronic Obstructive Pulmonary Disease
- VernacularTitle:Fas-FasL和TNF-?介导的细胞凋亡及IL-8在老年慢性阻塞性肺疾病发病机理中的作用
- Author:
Changhai LIU
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease(COPD);
Fas/FasL;
Tumor necrosis factor alpha(TNF-?);
(Interleukin)8(IL-8);
Apoptosis
- From:
Chinese Journal of Nosocomiology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the significance of the Fas and TNF-? receptor mediated apoptosis and IL-8 associated with the pathogenesis of aged COPD.METHODS We measured the circulating soluble Fas,tumor(necrosis) factor alpha(TNF-?) and interleukin-8 level in peripheral blood of 40 patients with aged chronic(obstructive) pulmonary disease (COPD).In contrast with the aged COPD group,30 healthy old people were(observed) as a control.RESULTS The level of soluble Fas,TNF-? and IL-8 in peripheral blood of these patients was higher than control((P
