Antibacterial Activities of Cefoperazone-sulbactam Against Gram-negative Bacilli
- VernacularTitle:头孢哌酮/舒巴坦对革兰阴性菌的抗菌活性
- Author:
Yajuan LI
;
Pengpeng LIU
;
Ping LI
;
Weiwei SUN
;
Xiaojia HAO
- Publication Type:Journal Article
- Keywords:
Gram negative bacteria;
Non-fermentative strains;
Cefoperazone-sulbactam;
Susceptibility test
- From:
Chinese Journal of Nosocomiology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the antibacterial activities of cefoperazone combined with sulbactam against Gram negative bacteria,and compare with other antimicrobial agents.METHODS The antibacterial activities of 10 frequently used antibiotics against 1 670 strains of clinical isolated Gram negative bacteria were studied by using agar dilution methods according to the NCCLS 2002.RESULTS The results showed imipenem was the most active tested against Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae,followed by cefoperazone-(sulbactam),which had similar activities as imipenem against the non-fermentative strains such as Pseudononas aeruginosa,and Acinetobacter spp,but cefoperazone-(sulbactam) had higher susceptibility to imipenem-(resistant) Stenotrophomonas maltophilia.CONCLUSIONS Cefoperazone-sulbactam has good and broad spectrum(antibacterial) activities especially against Gram negative(bacteria,) and is expected to have a bright prospect in the treatment of severe hospital infections induced by Gram negative bacteria.
