Expression of protein kinase C in multidrug resistant cells of colorectal carcinoma
- VernacularTitle:大肠癌多药耐药细胞蛋白激酶C的表达及作用
- Author:
Xiaofeng LI
- Publication Type:Journal Article
- Keywords:
radiation,ionizing;
intestine,large/pathology;
drug resistance,neoplasm;
intestinal neoplasms/drug therapy;
genes,MDR;
protein kinase C
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of protein kinase C(PKC) in multidrug resistant cells of colorectal carcinoma after ionizing irradiation and observe the effect of PKC on occurrence and development of the multidrug resistant.Methods The effect of PKC on multidrug resistant HCG-8 cells of colorectal carcinoma after treated with X-ray was detected by indirect immunofluorescence technique and flow cytometry.Results Compared with sham-irradiation group,the positive percentage of PKC was increased significantly(P
