?-Synuclein Aggregation and Parkinson's Disease: Factors Affecting The Aggregation of ?-Synuclein
- VernacularTitle:?-Synuclein聚集与帕金森病——影响?-synuclein蛋白聚集的因素
- Author:
Ling JIN
;
Hui YANG
- Publication Type:Journal Article
- Keywords:
?-synuclein, Parkinson's disease, Lewy bodies
- From:
Progress in Biochemistry and Biophysics
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. ?-Synuclein was the first"PD gene"to be discovered. The involvement of ?-synuclein in PD was first suspected after two different ?-synuclein mutations were identified in two kindreds with autosomal-dominant PD. However,the discovery that ?-synuclein is the major component of Lewy bodies-pathological hallmarks of PD, confirmed its role in PD pathogenesis. Pathological aggregation of ?-synuclein might be responsible for neurodegeneration. Multiple factors have been shown to affect ?-synuclein aggregation in vitro or in vivo. In addition, soluble oligomers of ?-synuclein might be even more toxic than the insoluble fibrils found in degenerative diseases. So it is significant to investigate factors affecting ?-synuclein aggregation, especially their accurate effects on the aggregation process.
