Effect of NF-?B and I?B on neuronal apoptosis of experimential presyrinx state in rabbits
- VernacularTitle:NF-?B和I?B对兔实验性脊髓空洞前状态神经元凋亡的影响
- Author:
Guozhu SUN
- Publication Type:Journal Article
- Keywords:
NF-?B;
presyrinx state;
neuronal apoptosis
- From:
Basic & Clinical Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of NF-?B and I?B on neuronal apoptosis of spinal presyrinx state in rabbits.Methods The experimental model of rabbits were established by intra-cisternal injection of kaolin.Neuronal apoptosis and the expression of NF?B、I?B、BCL-2、BAX were measured wih immunohistochemistry in 1,3,7,14 and(21 d) after operation repectively.Results In Kaolin group animals,neuronal apoptosis was observed in all time points,but was most significant from 7 to 14 day.Comparing with control groups,NF-?B expression in Kaolin group animals increased in 1~(st) day after operation,reached its peak at 3~(th) day,lasted to 7~(th) day,and recoved normal level at 21~(th) day approximately.I?B expression showed negative corelationship with NF-?B at the same time points.BCL-2 expression increased from 1~(st) day,reached its peak at 7~(th) day,lasted to 14~(th) day,and then began to drop.Although BAX expression had the similar trendency to BCL-2,the former was much stronger than the later.Conclusion In presyrinx state of experimental syringomyelia,increasing expression NF-?B's upregulates its target gene BAX and induces neuronal apoptosis in nervous function injury.
