Effect of Chronic Toxoplasma Infection on the Spatial Learning and Memory Capability in Mice
- VernacularTitle:弓形虫(RH株)慢性感染小鼠空间学习记忆能力的初步研究
- Author:
Huiling WANG
;
Anyu BAO
;
Gaohua WANG
;
Mingsen JIANG
;
Zhongchun LIU
;
Huifen DONG
;
Yi GUO
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
Chronic infection;
Morris Water Maze;
Spatial learning;
Memory
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of chronic infection of Toxoplasma gondii on the spatial learning and memory capability in mice.Methods Toxoplasma tachyzoites(RH strain)were reanimated at 37 ℃ after 15 days' storage at-20 ℃,and injected intraperitoneally to mice of the experimental group each with 7.7?105.Normal saline was given to the control group,0.5 ml per mouse.Two months later,all mice were tested in the Morris Water Maze.Smears of the mice brain homogenate and pathological sections were examined.Results ① The density of cysts in the brain homogenate was 15/HP,and there was no evident pathological change in the hippocampus and adjacent areas of mice in the brain in the experimental mice.② Latency to platform,cumulative distance to the platform,total distance traveled in both experimental and control groups decreased significantly with the increase of training days(P
