Changes of Peripheral Blood T Lymphocytes,IFN-?,TNF-? and IL-4 in Rats Infected by Toxoplasma gondii
- VernacularTitle:弓形虫感染大鼠外周血T淋巴细胞亚群及IFN-?、TNF-?、IL-4动态变化
- Author:
Chunli WANG
;
Yonghua ZHOU
;
Jianhu LIU
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
ELISA;
Flow cytometry;
CD4+?CD8+ T lymphocyte;
IFN-?;
TNF-?;
IL-4
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of peripheral blood T lymphocytes,IFN-?,TNF-? and IL-4 in rats infected by T.gondii.Methods 48 Sprague-Dawley(SD)rats were intra-abdominally injected with 2?105/L of cellulose purified living tachyzoites in 2 ml and randomly divided into 8 groups.Six rat was intra-abdominally injected 2 ml of saline as control and 4 rats were remained as normal control.Peripheral blood was collected and the level of IFN-?,TNF-?,IL-4 was analyzed by ELISA on day 1,3,7,14,28,35,42,60.Results Level of IFN-?(6.73 pg/ml)and IL-4(6.91 pg/ml)increased in experimental rats on day 7(P
