Inhibition of Quercetin on Liver Fibrosis due to Schistosoma japonicum Infection and on the Expression of Immediate Early Gene and Metalloproteinase 1 Inhibitor in Liver Tissue of Mice
- VernacularTitle:槲皮素抑制小鼠血吸虫病肝组织即早基因和基质金属蛋白酶组织抑制因子1的表达
- Author:
Biao XU
;
Shengsong HE
;
Chunrong HAN
- Publication Type:Journal Article
- Keywords:
Quercetin;
Schistosoma japonicum;
Liver fibrosis;
Immediate early gene;
TIMP1
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Quercetin and praziquantel were used to treat mice with hepatic fibrosis due to Schistosoma japonicum infection.Quercetin treatment obviously relieved the degree of hepatic fibrosis,significantly reduced the expression of immediate early gene,tissue inhibitor of metalloproteinase 1(TIMP 1),typesⅠ and Ⅲ collagen compared to the control.The expression of c-jun mRNA,typeⅠ and type Ⅲ collagen were reduced significantly compared to the group treated with praziquantel,whereas no difference in the expression of c-fos mRNA and TIMP1 between the two groups,indicating that quercetin may have better effect on schistosomal liver fibrosis than praziquantel in the long term.
