Immunomodulation of alcohol from ascidians(SCI) in mice
- VernacularTitle:海鞘醇(环二氧二甲基胆甾醇,SCI)对小鼠免疫功能的影响
- Author:
Xueping MA
- Publication Type:Journal Article
- Keywords:
ascidian;
thymus;
spleen;
phagocyte;
lymphcyte;
immunomodulation
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunomodulation of SCI in mice.Methods Effects of SCI on the immunity were studied by the observation of the index of lymphatic organ,the phagocytosis of the phagocytes and proliferation of splenocyte.Results SCI(4mg?kg~(-1)) could improve the index of thymus and proliferation of splenocyte.SCI(4,8,16mg?kg~(-1)) could also strengthen the phagocytosis of the phagocytes.But with the dose increased,a strend was observed of decreased phagocytosis of the phagocytes.Conclusion SCI could improve the index of thymus,strengthen the phagocytosis of the phagocytes and proliferation of splenocyte.The results indicates that SCI has the function of immunomodulation in mice.
