Long-term outcome of cardiac resynchronization therapy in patients with drug-refractory heart failure
- VernacularTitle:双心室同步起搏治疗难治性心力衰竭的长期临床疗效
- Author:
Fang WANG
;
Wei JIN
;
Jianjun ZHANG
- Publication Type:Journal Article
- Keywords:
Cardiac pacing, artifical;
Heart failure, congestive;
Treatment outcome
- From:
Chinese Journal of Interventional Cardiology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the long-term outcome of cardiac resynchronization therapy (CRT) in drug refractory heart failure patients through retrospective analysis and to ivestigate the underline reasons of unsuccessful cases in the study. Methods The study comprised a total of 48 patients (mean age 70?18.5 years; 83% male) with New York Heart Association class Ⅲ (86%) or class Ⅳ (14%) heart failure and LVEF≤35%. All patients fulfilled the standard CRT indications with the QRS duration ≥130 and LVEDd≥60 mm. Only one of the 48 patients was implanted with a combination of automatic implantable cardioverter-defibrillator and CRT device. The outcome of CRT was evaluated in terms of QRS duration, LVEF through echocardiography, 6 minute hall walk and tissue doppler echocardiography. Results Within a mean clinical follow-up of 29.0?7.5 month, the QRS duration was significantly shortened by biventricular pacing compared with right ventricular or left ventricular pacing. [(169?26) ms vs (188?40) ms and (222?34) ms vs (212?42) ms, respectively]. The NYHA functional class was improved from class Ⅲ-Ⅳ before the operation to class Ⅰ-Ⅱ at 1 week and 1 month during the follow up period. LVEF increased gradually from (28.30?3.94)% to (37.80?3.98)% after one week and increased to (42.99?7.87)% at the end of the follow-up. There was significant difference in LVEF before and 1 week after the operation (P
