Relationships between expressions of estrogen receptor, proliferating cell nuclear antigen in human prolactinomas and tumor invasiveness
- VernacularTitle:泌乳素腺瘤中雌激素受体和增殖细胞核抗原表达水平与肿瘤侵袭性的关系
- Author:
Youqiang CUI
;
Liangzhu TENG
;
Guoxin LI
- Publication Type:Journal Article
- Keywords:
prolactinomas;
estrogen receptor;
proliferating cell nuclear antigen
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between the expressions of estrogen receptor (ER), proliferating cell nuclear antigen (PCNA) in prolactinomas and tumor invasiveness. Methods The expressions of ER and PCNA proteins were examined by immunocytochemical method, including 24 invasive prolactinomas (invasive group) and 32 non-invasive prolactinomas (non-invasive group). The expression of ER-mRNA was detected by reverse transcription-polymerase chain raction (RT-PCR) technique. Results There were 23 cases of positive protein expression of ER in invasive group, the integral optical density (IOD) was 4935.12?1246.56, significantly lower than non-invasive group ( P
