Changes of synapsin Ⅰ expression and synaptic ultrastructure in hippocampus of the rat models of epilepsy
- VernacularTitle:癫大鼠海马区囊泡锚定蛋白Ⅰ的表达及突触超微结构的改变
- Author:
Guoshuai YANG
;
Jue HU
;
Bo XIAO
- Publication Type:Journal Article
- Keywords:
epilepsy;
synapsinⅠ;
ultrastructure;
synaptic plasticty
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To illuminate relationships between epilepsy and functional and morphologic plasticity of synapse through investigating temporal-spatial expression of syanpsinⅠand the alteration of synaptic ultrastructure in hippocampus after seizure. Methods The models of epilepsy were established by injection of pilocarpine and lithium. Electromicroscope and the software of image manipulation were applied to observe the alteration of synaptic ultrastructure in hippocampus during acute phase, resting phase and chronic phase. The expressions of synapsinⅠ were determined by immunohistochemistry. Results The expression of synapsinⅠin every subfield of hippocampus decreased at 3 h after induction of seizure, reached the peak at 6 h and 12 h, which was significantly different from the control ( P
