Effect of mild hypotherma on aquaporin 4 expressions and cerebral edema in experimental rats after intracerebral hemorrhage
- VernacularTitle:亚低温对实验性脑出血后水通道蛋白4表达及脑水肿的影响
- Author:
Xiaobin LI
;
Ruiguo DONG
;
Guangjun CHENG
- Publication Type:Journal Article
- Keywords:
mild hypothermia;
aquaporin 4;
brain edema;
cerebral hemorrhage
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of mild hypothermia on aquaporin 4 (AQP4) expressions and cerebral edema after intracerebral hemorrhage and the mechanisms of mild hypothermia on hemorrhagic brain edema. Methods The model of intracerebral hemorrhage (ICH) was established by infusing collagenase into right globus pallidus of the rat. The temperature was regulated by ice cubes and daylight lamp, which was modulated to an appropriate distance to the animals. Immunohistochemistry staining was used to detect the cerebral AQP4 expressions. Dynamic change of brain edema was observed through wet-dry weighing method. Results The brain water content (BWC) of injured side and level of AQP4 expression in perihematom tissue in ICH rats were obviously higher than those of the sham group (all P
