Preliminary studies on the preparation of polysaccharide from Sargassum thunbergii Kuntze(PST) and its anticoagulation activity
- VernacularTitle:鼠尾藻多糖的制备及其抗凝血活性的初步研究
- Author:
Yuxi WEI
- Publication Type:Journal Article
- Keywords:
polysaccharide from Sargassum thunbergii Kuntze;
bleeding time;
blood coagulation
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Polysaccharide from Sargassum thunbergii Kuntze(PST) was purified and degraded to study its anticoagulation activity.Diatomite was used for decolourization and NaCIO for degration of the polysaccharide to get three degraded products.Methods PST and the degraded products were applied in mice anticoagulation experiment by methods of cutting tail and capillary.Results All samples showed significant activities to extend bleeding time and blood coagulation time in mice,as well as to increase the amount of bleeding in mice.Conclusion Polysaccharide from Sargassum thunbergii Kuntze has significant anticoagulative activity and its anticoagulative activity is closely related with its molecular-weight.
